NDLI: Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies

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Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies

Content Provider	Scilit
Author	Fadiloglu, Erdem Tanacan, Atakan Unal, Canan Hakli, Duygu Aydin Beksac, Mehmet Sinan
Copyright Year	2019
Abstract	Objective: To demonstrate clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies. Methods: We retrospectively evaluated 75-g GTT screening results of 356 pregnancies without prompt diagnosis of gestational diabetes mellitus (GDM) between January 2013 and December 2017. Newborns with a birthweight greater than the 90^th percentile were evaluated as LGA. Pregnancies with LGA and non-LGA fetuses were compared by demographic and historical factors – maternal age, gravidity, parity, birthweight, birthweek, GTT results and birthweight percentiles – via Student’s t-test. Multiple linear regression using the backward elimination method was performed to define the correlation between parameters and LGA (P-value of <0.20 was identified as the threshold). Receiver operator characteristics (ROC) curve analysis was performed for further analysis. Results: The cohort was consisted of 45 (12.6%) and 311 (87.4%) pregnancies with LGA and non-LGA fetuses, respectively. Maternal age and 2^nd-h GTT results were found to be significantly higher in patients with LGA newborns (P<0.001 and P=0.016, respectively). Fasting glucose levels and GTT 1^st-h results were also higher (P=0.112, P=0.065). The coefficient of multiple determination (R²) was 0.055 by multiple linear regression analysis. Accordingly, GTT 2^nd-h result and maternal age were statistically significant and contributed to the explanation of LGA, although the R² value was not that much higher (P=0.016; P=0.001). Maternal age and GTT 2^nd-h results were found to be associated with LGA fetuses with area under the curve (AUC) values of 0.662 and 0.608 according to ROC curve analysis. Conclusion: Maternal age and 75-g GTT 2^nd-h results were significantly higher in gestations with LGA newborns without GDM.
Related Links	http://www.degruyter.com/downloadpdf/j/jpme.ahead-of-print/jpm-2018-0373/jpm-2018-0373.xml
Ending Page	538
Page Count	5
Starting Page	534
ISSN	16193997
e-ISSN	03005577
DOI	10.1515/jpm-2018-0373
Journal	Journal of Perinatal Medicine
Issue Number	5
Volume Number	47
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2019-07-26
Access Restriction	Open
Subject Keyword	Journal of Perinatal Medicine Integrative and Complementary Medicine 75-g Glucose Tolerance Test Diabetes Mellitus Diabetes Screening Large for Gestational Age Pregnancy Journal: Journal of Perinatal Medicine, Vol- 47, Issue- 1
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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