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Comparison between Pseudomonas aeruginosa siderophores and desferrioxamine for iron acquisition from ferritin
| Content Provider | Scilit |
|---|---|
| Author | Srifuengfung, Somporn Assanasen, Susan Tuntawiroon, Malulee Meejanpetch, Sumonrat |
| Copyright Year | 2010 |
| Abstract | Background: Siderophore is an iron chelator produced by microorganism. Pseudomonas aeruginosa produces two siderophores (pyoverdin and pyochelin). Desferrioxamine is a siderophore used in thalassemia patients to treat an iron overload of vital organs. Objective: Compare the ability of pyoverdin, pyochelin, and desferrioxamine for iron mobilization from ferritin. Materials and Methods: In vitro experiment, the ability of P. aeruginosa siderophores and desferrioxamine for iron mobilization from ferritin was compared by using a dialysis membrane assay at pH values of 7.4 and 6.0. Stimulation of P. aeruginosa PAO1 growth by all siderophores was studied in glucose minimum medium. Results: All three compounds were capable of iron mobilization at both pHs. At pH 6.0, the most effectiveness compound was desferrioxamine (31.6%), followed by pyoverdin (21.5%) and pyochelin (13.7%) compared on weight basis, each at 10 μg/mL. At equimolar concentration, their activities were desferrioxamine (38.5±1.2%), followed by pyoverdin (32.0±4.8%) and pyochelin (26.7±1.9%), respectively. Conclusion: The most effective compound in iron mobilization from ferritin was desferrioxamine, followed by pyoverdin and pyochelin respectively. |
| Related Links | https://content.sciendo.com/downloadpdf/journals/abm/4/4/article-p631.pdf http://www.degruyter.com/downloadpdf/j/abm.2010.4.issue-4/abm-2010-0080/abm-2010-0080.xml |
| Ending Page | 635 |
| Page Count | 5 |
| Starting Page | 631 |
| e-ISSN | 1875855X |
| DOI | 10.2478/abm-2010-0080 |
| Journal | Asian Biomedicine |
| Issue Number | 4 |
| Volume Number | 4 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2010-08-01 |
| Access Restriction | Open |
| Subject Keyword | Asian Biomedicine Medical Laboratory Technology Nutrition and Dietetics Pseudomonas Microorganism Compound Aeruginosa Desferrioxamine for Iron Siderophores and Desferrioxamine Ferritin Journal: Asian Biomedicine, Vol- 4 |
| Content Type | Text |
| Resource Type | Article |
