NDLI: Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases

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Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases

Content Provider	Scilit
Author	Hosoi, Toru Nomura, Jun Tanaka, Keigo Ozawa, Koichiro Nishi, Akinori Nomura, Yasuyuki
Copyright Year	2017
Abstract	Increasing evidence suggests that endoplasmic reticulum (ER) stress and autophagy play an important role in regulating brain function. ER stress activates three major branches of the unfolded protein response (UPR) pathways, namely inositol-requiring enzyme-1 (IRE1), double stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK) and activating transcription factor 6 (ATF6)-mediated pathways. Recent studies have suggested that these UPR signals may be linked to autophagy. In this review article, we summarize recent evidence and discuss a possible link between ER stress and autophagy with regard to neurodegenerative diseases. Furthermore, possible pharmacological strategies targeting UPR and autophagy are discussed.
Related Links	http://www.degruyter.com/downloadpdf/j/ersc.2017.4.issue-1/ersc-2017-0004/ersc-2017-0004.xml
Ending Page	45
Page Count	9
Starting Page	37
ISSN	23004266
e-ISSN	23004266
DOI	10.1515/ersc-2017-0004
Journal	Endoplasmic Reticulum Stress in Diseases
Issue Number	1
Volume Number	4
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2017-11-16
Access Restriction	Open
Subject Keyword	Endoplasmic Reticulum Stress in Diseases Geriatrics Endoplasmic Reticulum Stress Unfolded Protein Response Neurodegenerative Diseases Autophagy Journal: Endoplasmic Reticulum Stress in Diseases, Issue- 2
Content Type	Text
Resource Type	Article

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