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Synthesis of a Regular 24-membered Cyclodepsipeptide by Direct Amide Cyclization
| Content Provider | Scilit |
|---|---|
| Author | Kottgen, Peter Linden, Anthony Heimgartner, Heinz |
| Copyright Year | 2009 |
| Abstract | The synthesis of a 24-membered cyclic depsipeptide with an alternating sequence of phenyllactic acid and α-aminoisobutyric acid (Aib) is described. The linear precursor was prepared via the ‘azirine/oxazolone method’ using 2,2-dimethyl-3-amino-2H-azirines as building blocks for the α,α-disubstituted α-amino acid Aib. The macrolactonization leading to the cyclodepsipeptide was achieved by the ‘direct amide cyclization’, i. e., by treatment of a solution of the linear precursor in toluene with HCl gas. |
| Related Links | http://www.degruyter.com/downloadpdf/j/znb.2009.64.issue-6/znb-2009-0615/znb-2009-0615.xml |
| Ending Page | 698 |
| Page Count | 10 |
| Starting Page | 689 |
| ISSN | 09320776 |
| e-ISSN | 18657117 |
| DOI | 10.1515/znb-2009-0615 |
| Journal | Zeitschrift für Naturforschung B |
| Issue Number | 6 |
| Volume Number | 64 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2009-06-01 |
| Access Restriction | Open |
| Subject Keyword | Zeitschrift Für Naturforschung B Organic Chemistry Building Cyclodepsipeptide Membered Treatment Direct Amide Cyclization Amino Journal: Zeitschrift für Naturforschung B, Vol- 64 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
