NDLI: Efficacy of Recombinant Human Growth Hormone in Children with Juvenile Rheumatoid Arthritis and Growth Failure

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Efficacy of Recombinant Human Growth Hormone in Children with Juvenile Rheumatoid Arthritis and Growth Failure

Content Provider	Scilit
Author	Al-Mutair, A. Bahabri, S. Al-Mayouf, S. Al-Ashwal, A.
Copyright Year	2000
Abstract	Ten patients with juvenile rheumatoid arthritis (JRA) and growth failure were treated with recombinant human growth hormone (GH) for 1 to 3 years at a dosage of 0.57 IU/kg/wk. All the patients had been on prednisone at a mean dosage of 4.12 mg p.o. daily. GH was low in one patient, two patients had a borderline level and seven patients had adequate response to provocative tests or post-sleep measurement. Serum IGF-I was found to be low in five of six patients. Mean growth velocity increased from 2.45 cm/yr to 4.79 cm/yr after 1 year's treatment with GH (P<0.004). Six patients continued on GH treatment for a second year and continued to have a better growth velocity, with a mean of 5.43 cm/yr (P<0.014). Two patients entered puberty during the second year of GH treatment. This study demonstrates the potential beneficial effect of GH treatment in patients with JRA with growth failure of systemic onset or polyarticular onset who are on prednisone. Further study is needed to determine the long-term effect of GH treatment on ultimate height.
Related Links	http://www.degruyter.com/downloadpdf/j/jpem.2000.13.7/jpem.2000.13.7.899/jpem.2000.13.7.899.xml
Ending Page	906
Page Count	8
Starting Page	899
ISSN	21910251
DOI	10.1515/jpem.2000.13.7.899
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	7
Volume Number	13
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2000-01-01
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Endocrinology and Metabolism Children Treatment Efficacy Arthritis Rheumatoid Juvenile Hormone Recombinant Prednisone Jra Efﬁcacy Journal: Journal of Pediatric Endocrinology and Metabolism, Vol- 13
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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