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Hydrogels from chitosan crosslinked with poly(ethylene glycol) diacid as bone regeneration materials
| Content Provider | Scilit |
|---|---|
| Author | Mincheva, Rosica Manolova, Nevena Sabov, Rumen Kjurkchiev, Galen Rashkov, Iliya |
| Copyright Year | 2004 |
| Abstract | A simple method to covalently crosslink chitosan using poly(ethylene glycol) diacid as crosslinking agent is proposed. Networks net-chitosan-ι- PEG(COOH)2 were obtained by heating chitosan in aqueous PEG600(COOH)2 solutions at a temperature higher than 60°C. IR spectroscopy revealed the formation of amide bonds. It is shown that the obtained chemical networks are pH-sensitive hydrogels with enhanced hydrophilicity. The equilibrium degree of swelling of the hydrogels is determined by the conditions of their preparation - heating temperature and mole ratio between chitosan and the crosslinker. The ability of the polymer networks to facilitate bone regeneration processes was shown by in vivo implantation experiments. |
| Related Links | http://www.degruyter.com/downloadpdf/j/epoly.2004.4.issue-1/epoly.2004.4.1.643/epoly.2004.4.1.643.xml http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/$002fj$002fepoly.2004.4.issue-1$002fepoly.2004.4.1.643$002fepoly.2004.4.1.643.pdf?t:ac=j$002fepoly.2004.4.issue-1$002fepoly.2004.4.1.643$002fepoly.2004.4.1.643.xml |
| Ending Page | 653 |
| Page Count | 11 |
| Starting Page | 643 |
| ISSN | 21974586 |
| e-ISSN | 16187229 |
| DOI | 10.1515/epoly.2004.4.1.643 |
| Journal | e-Polymers |
| Issue Number | 1 |
| Volume Number | 4 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2004-12-01 |
| Access Restriction | Open |
| Subject Keyword | E-polymers Biomaterials Hydrogels Chitosan Crosslinked Diacid Ethylene Regeneration Poly Cooh Glycol Journal: e-Polymers, Issue- 4 |
| Content Type | Text |
| Resource Type | Article |
