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Impact of adipose tissue on prostate cancer aggressiveness – analysis of a high-risk population
| Content Provider | Scilit |
|---|---|
| Author | Delouya, Guila Tiberi, David Bhatnagar, Sahir R. Campeau, Shanie Saad, Fred Taussky, Daniel |
| Copyright Year | 2018 |
| Abstract | Background We investigated whether visceral adiposity is associated with more aggressive disease at prostatectomy. Materials and methods Four hundred and seventy-four patients referred for postoperative adjuvant or salvage radiotherapy were included in this study. Primary endpoints were positive surgical margins (pSM) or extracapsular extension (ECE). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were manually contoured. Univariate and multivariate logistic regression was performed. Results In univariate analysis, VAT volume (p = 0.006), adipose tissue ratio (VAT/SAT, p = 0.003), density of the SAT (p = 0.04), as well as age (p < 0.001) were associated with pSM. In the univariate analysis, SAT density was associated with a trend towards a higher rate of ECE (p = 0.051) but visceral fat volume (p = 0.01), as well as the adipose tissue ratio (p = 0.03) were both protective factors. None of the adipose tissue measurements or BMI had an influence on biochemical recurrence or overall survival (all p ≥ 0.5). Conclusions SAT-volume and increased SAT-density were generally associated with more aggressive prostate cancers whereas VAT as a protective factor. These findings emphasize a possible mechanism for the association between obesity and prostate cancer aggressiveness. |
| Related Links | http://www.degruyter.com/downloadpdf/j/hmbci.ahead-of-print/hmbci-2018-0049/hmbci-2018-0049.xml |
| ISSN | 18681883 |
| e-ISSN | 18681891 |
| DOI | 10.1515/hmbci-2018-0049 |
| Journal | Hormone molecular biology and clinical investigation |
| Issue Number | 3 |
| Volume Number | 36 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2018-12-19 |
| Access Restriction | Open |
| Subject Keyword | Hormone Molecular Biology and Clinical Investigation Andrology Extracapsular Extension Fat Density Obesity Positive Surgical Margins Prostate Cancer Visceral Fat Journal: Hormone molecular biology and clinical investigation, Issue- 3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Molecular Biology Endocrinology |
