NDLI: Functional polyurethane nanomicelle with pH-responsive drug delivery property

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Functional polyurethane nanomicelle with pH-responsive drug delivery property

Content Provider	Scilit
Author	Song, Yifan Chai, Yun Xu, Kai Zhang, Puyu
Copyright Year	2018
Abstract	A new functional pH-responsive polyurethane-based nanomicelle has been developed with BES-Na as the functional monomer, the buffering agent with tertiary amine, and sulfonic acid group was incorporated into the hydrophilic shell as the functional agent, which resulted in polyurethane nanosystem with pH-sensitive property. Folic acid (FA) was chosen as model hydrophobic drug to evaluate the loading and pH-triggered release of the PU micelles in vitro drug loading and release. The drug loading content (LC) and the encapsulation efficiency (EE) for FA-loaded micelles in phosphate-buffered solutions were 7.68% and 27.72%, respectively, and the largest accumulative drug release percentages in pH 6.8 and pH 5.0 were 79.17% and 89.83% in 24 h, respectively. A facile and versatile approach has been provided for the design and fabrication of smart nanovehicles for effective drug delivery and opens a new thought in the design and fabrication of biodegradable polyurethanes for next generation of nanomicellar systems.
Related Links	http://www.degruyter.com/downloadpdf/j/epoly.ahead-of-print/epoly-2018-0030/epoly-2018-0030.xml
Ending Page	417
Page Count	9
Starting Page	409
ISSN	21974586
e-ISSN	16187229
DOI	10.1515/epoly-2018-0030
Journal	e-Polymers
Issue Number	5
Volume Number	18
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2018-07-12
Access Restriction	Open
Subject Keyword	E-polymers Biomaterials Drug Delivery Functional Nanomicelle Ph-responsive Polyurethane Journal: e-Polymers, Vol- 18
Content Type	Text
Resource Type	Article

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