NDLI: Serum level of NPTX1 is independent of serum MKRN3 in central precocious puberty

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Serum level of NPTX1 is independent of serum MKRN3 in central precocious puberty

Content Provider	Scilit
Author	Jeong, Hwal Rim Yoon, Jong Seo Lee, Hye Jin Shim, Yeong Suk Kang, Min Jae Hwang, Il Tae
Copyright Year	2020
Abstract	Objectives Makorin ring finger protein 3 (MKRN3) is associated with the initiation of puberty, and loss of function mutation of MKRN3 is the most common genetic cause of central precocious puberty (CPP). A recent study reported that MKRN3 interacts with and suppresses neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in the mouse hypothalamus. This study investigated the correlation between serum NPTX1 and MKRN3 in CPP girls and predicted the potential role of NPTX1 in pubertal progression. Methods In this case–control study, we examined 34 girls diagnosed with CPP and 34 healthy prepubertal girls. Anthropometric and hormonal parameters were measured and serum levels of NPTX1 and MKRN3 were evaluated with commercial enzyme-linked immunosorbent assay kits. Results Serum MKRN3 level decreased significantly in CPP patients compared to controls (344.48 ± 333.77 and 1295.21 ± 780.80 pg/mL, respectively, p
Related Links	https://www.degruyter.com/downloadpdf/journals/jpem/ahead-of-print/article-10.1515-jpem-2020-0402/article-10.1515-jpem-2020-0402.pdf
Ending Page	63
Page Count	5
Starting Page	59
ISSN	21910251
DOI	10.1515/jpem-2020-0402
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	1
Volume Number	34
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2021-01-27
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Endocrinology and Metabolism Precocious Puberty Mkrn3 Nptx1 Journal: Journal of Pediatric Endocrinology and Metabolism, Issue- 3-4
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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