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Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
| Content Provider | Scilit |
|---|---|
| Author | Kelley, Darshan S. Vemuri, Madhuri Adkins, Yuriko Gill, Sher Himmat S. Fedor, Dawn Mackey, Bruce E. |
| Copyright Year | 2008 |
| Description | Insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) are found in 35 and 30 % of US adults, respectively. Trans-10, cis-12-conjugated linoleic acid (CLA) has been found to cause both these disorders in several animal models. We hypothesised that IR and NAFLD caused by CLA result from n-3 fatty acid deficiency. Pathogen-free C57BL/6N female mice (aged 8 weeks; n 10) were fed either a control diet or diets containing trans-10, cis-12-CLA (0·5 %) or CLA+flaxseed oil (FSO) (0·5 %+0·5 %) for 8 weeks. Weights of livers, concentration of circulating insulin, values of homeostatic model 1 (HOMA1) for IR and HOMA1 for β cell function were higher by 160, 636, 985 and 968 % in the CLA group compared with those in the control group. FSO decreased fasting glucose by 20 % and liver weights by 37 % compared with those in the CLA group; it maintained circulating insulin, HOMA1-IR and HOMA1 for β cell function at levels found in the control group. CLA supplementation decreased n-6 and n-3 wt% concentrations of liver lipids by 57 and 73 % and increased the n-6:n-3 ratio by 58 % compared with corresponding values in the control group. FSO increased n-6 and n-3 PUFA in liver lipids by 33 and 342 % and decreased the n-6:n-3 ratio by 70 % compared with corresponding values in the CLA group. The present results suggest that some adverse effects of CLA may be due to n-3 PUFA deficiency and that these can be corrected by a concomitant increase in the intake of α-linolenic acid, 18 : 3n-3. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/3404CA0497D670030AD107E1E464D08F/S0007114508027451a.pdf/div-class-title-flaxseed-oil-prevents-span-class-italic-trans-span-10-span-class-italic-cis-span-12-conjugated-linoleic-acid-induced-insulin-resistance-in-mice-div.pdf |
| Ending Page | 708 |
| Page Count | 8 |
| Starting Page | 701 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114508027451 |
| Journal | British Journal Of Nutrition |
| Issue Number | 5 |
| Volume Number | 101 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2009-03-14 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics linolenic Acid 3 Polyunsaturated Fatty Acids alcoholic Fatty Liver Disease Cardiovascular Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
