NDLI: Integrin-like RGD-dependent cell adhesion mechanism is involved in the rapid killing of Onchocerca microfilariae during early infection of Simulium damnosum s.l.

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Integrin-like RGD-dependent cell adhesion mechanism is involved in the rapid killing of Onchocerca microfilariae during early infection of Simulium damnosum s.l.

Content Provider	Scilit
Author	Hagen, H. E. Kläger, S. L.
Copyright Year	2001
Description	Injection trials with compatible and non-compatible Onchocerca species into S. damnosum s.l., the vector of human and bovine onchocerciasis, demonstrated that the rapid killing of microfilariae within the blackfly's haemocoel is species specific. In the presence of the peptide RGDS as a blocking agent for integrin-like receptors of haemocytes, the survival of O. ochengi microfilariae in its natural intermediate host was significantly increased. This increased survival 24 h p.i. correlated with a significant decrease of apoptosis levels in the microfilariae following a 2 h exposure to the haemolymph in vivo. These findings suggest that haemocytes are directly involved in the killing of Onchocerca microfilariae in the blackfly.
Related Links	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/24829826F885BBF321258B2468482E33/S0031182001007545a.pdf/div-class-title-integrin-like-rgd-dependent-cell-adhesion-mechanism-is-involved-in-the-rapid-killing-of-span-class-italic-onchocerca-span-microfilariae-during-early-infection-of-span-class-italic-simulium-damnosum-span-s-l-div.pdf
Ending Page	438
Page Count	6
Starting Page	433
ISSN	00311820
e-ISSN	14698161
DOI	10.1017/s0031182001007545
Journal	Parasitology
Issue Number	4
Volume Number	122
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2001-02-01
Access Restriction	Open
Subject Keyword	Parasitology Natural Killer Cells Simulium Damnosum Onchocerca Ochengi Filarial Infection
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Animal Science and Zoology

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