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Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China
| Content Provider | Scilit |
|---|---|
| Author | Gu, Y. Yi, M. Xu, Y. Zhao, H. Fu, F. Zhang, Y. |
| Copyright Year | 2015 |
| Description | SUMMARY High-risk human papillomaviruses (HPVs) are highly prevalent worldwide, and HPV genotype distribution varies regionally. Molecular surveys of HPVs are important for effective HPV control and prevention. Fifteen high-risk HPV strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68) and six low-risk HPV strains (HPV6, 11, 42, 43, 44, CP8304) were detected by cervical cytology from 10 501 subjects. High-risk HPVs, low-risk HPVs, and both high- and low-risk HPVs were detected in 14·5%, 2·8%, and 2·4% of cases, respectively. Of 1782 subjects with high-risk HPV infection, 75·5%, 18·1%, and 6·4% were infected with one, two, and ⩾3 strains of high-risk HPVs, respectively. HPV52, HPV16, and HPV58 were the top three most dominant high-risk HPV genotypes in our population with positivity rates of 23·0%, 17·7% and 16·9%, respectively. Multiple infection was common, with significantly higher co-infection rates of HPV58/HPV33 (12·9%) and HPV58/HPV52 (11·3%). Further data comparisons showed that HPV genotype distribution varied markedly between domestic and international regions. In conclusion, a monolithic vaccination strategy is obviously impractical, and regional HPV surveillance is essential to optimize current HPV control and prevention. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/659DB07C01E84B29E779B6007B63E2A1/S0950268815002721a.pdf/div-class-title-genotype-distribution-characteristics-of-high-risk-human-papillomaviruses-in-women-from-shanghai-china-div.pdf |
| Ending Page | 1489 |
| Page Count | 8 |
| Starting Page | 1482 |
| ISSN | 09502688 |
| e-ISSN | 14694409 |
| DOI | 10.1017/s0950268815002721 |
| Journal | Epidemiology and Infection |
| Issue Number | 7 |
| Volume Number | 144 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2016-05-01 |
| Access Restriction | Open |
| Subject Keyword | Epidemiology and Infection Human Papilloma Virus (hpv) Molecular Survey Viral Strain Distribution |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology |
