The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics

Content Provider	Scilit
Author	Mizrahi, Romina Mamo, David Rusjan, Pablo Graff, Ariel Houle, Sylvain Kapur, Shitij
Copyright Year	2009
Description	Antipsychotic drugs produce unpleasant subjective experiences, which have been associated with high levels of dopamine $D_{2}$ receptor occupancy. Aripiprazole is a partial agonist antipsychotic, which is hypothesized to produce a different subjective experience profile compared to standard $D_{2}$ antagonist antipsychotics. The aim of this study was to compare the effect of $D_{2}$ occupancy produced by a partial agonist antipsychotic (aripiprazole) to that of antagonist antipsychotics (risperidone or olanzapine) on the subjective well-being of patients. Subjective well-being was measured using the Subjective Well-being under Neuroleptics Scale (SWN) and was related to dopamine $D_{2}$ receptor occupancy using $[^{11}$C]raclopride PET. Patients that were switched to aripiprazole showed improvement in their subjective well-being from 79.80 (s.d.=16.08) to 89.90 (s.d.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA $D_{2}$ occupancy (82–99%), in contrast to the effects of antagonist antipsychotics on subjective well-being.
Related Links	https://core.ac.uk/download/pdf/132620039.pdf https://academic.oup.com/ijnp/article-pdf/12/5/715/2168170/12-5-715.pdf
Ending Page	721
Page Count	7
Starting Page	715
DOI	10.1017/s1461145709000327
Journal	International Journal of Neuropsychopharmacology
Issue Number	5
Volume Number	12
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2009-04-15
Access Restriction	Open
Subject Keyword	International Journal of Neuropsychopharmacology Biological Psychology Subjective Well D2 Receptor Dopamine D2 Antagonist Antipsychotics
Content Type	Text
Resource Type	Article