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Effects of the dopamine transporter gene on striatal functional connectivity in youths with attention-deficit/hyperactivity disorder
| Content Provider | Scilit |
|---|---|
| Author | Shang, Chi-Yung Lin, Hsiang-Yuan Gau, Susan Shur-Fen |
| Copyright Year | 2020 |
| Description | Background: The dopamine transporter gene (DAT1), striatal network dysfunction, and visual memory deficits have been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). This study aimed to examine the effects of the DAT1 rs27048 (C)/rs429699 (T) haplotype on striatal functional connectivity and visual memory performance in youths with ADHD.Method: After excluding those who had excessive head motion, a total of 96 drug-naïve youths with ADHD and 114 typically developing (TD) youths were assessed with the resting-state functional magnetic resonance imaging and the delayed matching to sample (DMS) task for visual memory. We examined the effects of ADHD, DAT1 CT haplotype, and the ADHD × CT haplotype interaction on the functional connectivity of five striatal seeds. We also correlated visual memory performance with the functional connectivity of striatal subregions, which showed significant diagnosis × genotype interactions.Results: Compared with TD youths, ADHD youths showed significant hypoconnectivity of the left dorsal caudate (DC) with bilateral sensorimotor clusters. Significant diagnosis × genotype interactions were found in the connectivity between the left DC and the right sensorimotor cluster, and between the right DC and the left dorsolateral prefrontal/bilateral anterior cingulate clusters. Furthermore, the connectivity of the left DC showing significant diagnosis × genotype interactions was associated with DMS performance in youths with ADHD who carried the DAT1 CT haplotype.Conclusions: A novel gene-brain-behavior association between the left DC functional connectivity and visual memory performance in ADHD youths with the DAT1 rs27048 (C)/rs429699 (T) haplotype suggests a differential effect of DAT1 genotype altering specific brain function causing neuropsychological dysfunction in ADHD. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/76478F78D36A053E089B5F0F1258ED02/S0033291719003830a.pdf/div-class-title-effects-of-the-dopamine-transporter-gene-on-striatal-functional-connectivity-in-youths-with-attention-deficit-hyperactivity-disorder-div.pdf |
| Ending Page | 845 |
| Page Count | 11 |
| Starting Page | 835 |
| ISSN | 00332917 |
| e-ISSN | 14698978 |
| DOI | 10.1017/s0033291719003830 |
| Journal | Psychological Medicine |
| Issue Number | 5 |
| Volume Number | 51 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2021-04-01 |
| Access Restriction | Open |
| Subject Keyword | Psychological Medicine Psychiatry and Mental Health Attention Deficit Hyperactivity Disorder Dopamine Transporter Gene Functional Connectivity Resting Brain Imaging Visual Memory |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Psychology Psychiatry and Mental Health |
