Impaired probabilistic reversal learning in youths with mood and anxiety disorders

Content Provider	Scilit
Author	Dickstein, D. P. Finger, E. C. Brotman, M. A. Rich, B. A. Pine, D. S. Blair, J. R. Leibenluft, E.
Copyright Year	2009
Description	From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls. We administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ. Compared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07). Our results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.
Related Links	http://europepmc.org/articles/pmc3000432?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000432/pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/3C8DE5636BA78765DBB2FE097EC9D024/S0033291709991462a.pdf/div-class-title-impaired-probabilistic-reversal-learning-in-youths-with-mood-and-anxiety-disorders-div.pdf
Ending Page	1100
Page Count	12
Starting Page	1089
ISSN	00332917
e-ISSN	14698978
DOI	10.1017/s0033291709991462
Journal	Psychological Medicine
Issue Number	7
Volume Number	40
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2010-07-01
Access Restriction	Open
Subject Keyword	Psychological Medicine Psychiatry and Mental Health Anxiety Disorders Bipolar Disorder Psychological Tasks Reversal Learning
Content Type	Text
Resource Type	Article
Subject	Applied Psychology Psychiatry and Mental Health