NDLI: Murine models provide insight to the development of non-alcoholic fatty liver disease

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Murine models provide insight to the development of non-alcoholic fatty liver disease

Content Provider	Scilit
Author	Reid, D. T. Eksteen, B.
Copyright Year	2015
Description	Associated with the obesity epidemic, non-alcoholic fatty liver disease (NAFLD) has become the leading liver disease in North America. Approximately 30 % of patients with NAFLD may develop non-alcoholic steatohepatitis (NASH) that can lead to cirrhosis and hepatocellular carcinoma (HCC). Frequently animal models are used to help identify underlying factors contributing to NAFLD including insulin resistance, dysregulated lipid metabolism and mitochondrial stress. However, studying the inflammatory, progressive nature of NASH in the context of obesity has proven to be a challenge in mice. Although the development of effective treatment strategies for NAFLD and NASH is gaining momentum, the field is hindered by a lack of a concise animal model that reflects the development of liver disease during obesity and the metabolic syndrome. Therefore, selecting an animal model to study NAFLD or NASH must be done carefully to ensure the optimal application. The most widely used animal models have been reviewed highlighting their advantages and disadvantages to studying NAFLD and NASH specifically in the context of obesity.
Related Links	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/1C6A3FC09EECFC9E6CE0A625449277AD/S0954422415000128a.pdf/div-class-title-murine-models-provide-insight-to-the-development-of-non-alcoholic-fatty-liver-disease-div.pdf
Ending Page	142
Page Count	10
Starting Page	133
ISSN	09544224
e-ISSN	14752700
DOI	10.1017/s0954422415000128
Journal	Nutrition research reviews
Issue Number	2
Volume Number	28
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2015-12-01
Access Restriction	Open
Subject Keyword	Nutrition research reviews Gastroenterology and Hepatology alcoholic Fatty Liver alcoholic Steatohepatitis Animal Models Alanine Aminotransferase Hepatocellular Carcinoma fat Diet deficient alcoholic Fatty Liver Disease Total Parenteral Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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