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The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
| Content Provider | Scilit |
|---|---|
| Author | Weamer, Elise A. Emanuel, James E. Varon, Daniel Miyahara, Sachiko Wilkosz, Patricia A. Lopez, Oscar L. DeKosky, Steven T. Sweet, Robert A. |
| Copyright Year | 2008 |
| Description | Background: Psychotic symptoms in Alzheimer disease (AD + P) identify a heritable phenotype associated with greater cognitive impairment. Knowing when the cognitive course of AD + P subjects diverges from that of subjects without psychosis would enhance understanding of how genetic variation results in AD + P and its associated cognitive burden. This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset.Methods: 361 subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis were evaluated every 6 months until psychosis onset.Results: Severity of cognitive dysfunction was a strong predictor of AD + P up to two years prior to psychosis onset. Cognition did not decline more rapidly prior to onset of AD + P.Conclusions: Individuals who will develop AD + P already demonstrate excess cognitive impairment during the mild stages of disease. Genetic variation and brain pathophysiology may lead to a cognitive risk phenotype which is present prior to dementia onset. |
| Related Links | http://europepmc.org/articles/pmc2678562?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678562/pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5E1C4056D70DB28751B4F7FCB3C50A27/S1041610208007734a.pdf/div-class-title-the-relationship-of-excess-cognitive-impairment-in-mci-and-early-alzheimer-s-disease-to-the-subsequent-emergence-of-psychosis-div.pdf |
| Ending Page | 85 |
| Page Count | 8 |
| Starting Page | 78 |
| ISSN | 10416102 |
| e-ISSN | 1741203X |
| DOI | 10.1017/s1041610208007734 |
| Journal | International Psychogeriatrics |
| Issue Number | 01 |
| Volume Number | 21 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2009-02-01 |
| Access Restriction | Open |
| Subject Keyword | International Psychogeriatrics Alzheimer's Disease Mci (mild Cognitive Impairment) Cognitive Neuropsychology in Dementia dementia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gerontology Clinical Psychology Geriatrics and Gerontology Psychiatry and Mental Health |
