Loading...
Please wait, while we are loading the content...
Similar Documents
Association between pre-pregnancy weight status and maternal micronutrient status in early pregnancy
| Content Provider | Scilit |
|---|---|
| Author | Scholing, Judith M. Olthof, Margreet R. Vrijkotte, Tanja Gm |
| Copyright Year | 2018 |
| Abstract | Objective: Inadequate maternal micronutrient status during pregnancy can lead to short- and long-term health risks for mother and offspring. The present study investigated the association between pre-pregnancy weight status and micronutrient status during pregnancy.Design: Maternal blood samples were collected during early pregnancy (median 13, interquartile range 12–15 weeks) and were assayed for serum folate, ferritin, Fe and vitamin $B_{12}$. Regression modelling was used to assess the association between pre-pregnancy underweight, normal weight, overweight and obesity, and micronutrient levels, as well as the odds for deficiencies.Setting: The Amsterdam Born Children and their Development (ABCD) study, the Netherlands.Subjects: Women with singleton pregnancies without diabetes (n 4243).Results: After adjustment for covariates, overweight women and obese women had lower (β; 95 % CI) folate (−1·2; −2·2, −0·2 and −2·3; −4·0, −0·7 nmol/l, respectively) and Fe (−1·7; −2·3, −1·1 and −3·6; −4·7, −2·6 μmol/l, respectively) levels than women with normal weight. Furthermore, overweight women had 6 % (95 % CI −9, −3 %) and obese women had 15 % (−19, −10 %), lower vitamin $B_{12}$ levels, and obese women had 19 % (6, 32 %) higher ferritin levels, than normal-weight women. Obese women had higher odds (OR; 95 % CI) for folate deficiency (2·03; 1·35, 3·06), Fe deficiency (3·26; 2·09, 5·08) and vitamin $B_{12}$ deficiency (2·05; 1·41, 2·99) than women with normal weight. Underweight was not associated with micronutrient status.Conclusions: During early pregnancy, women with pre-pregnancy overweight and obesity had lower serum folate, Fe and vitamin $B_{12}$ status. This resulted in increased risk of serum folate, Fe and vitamin $B_{12}$ deficiencies in women with obesity. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/1CE6509ADABC46F63A0C20D5385066F6/S1368980018000459a.pdf/div-class-title-association-between-pre-pregnancy-weight-status-and-maternal-micronutrient-status-in-early-pregnancy-div.pdf |
| Ending Page | 2055 |
| Page Count | 10 |
| Starting Page | 2046 |
| ISSN | 13689800 |
| e-ISSN | 14752727 |
| DOI | 10.1017/s1368980018000459 |
| Journal | Public Health Nutrition |
| Issue Number | 11 |
| Volume Number | 21 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2018-08-01 |
| Access Restriction | Open |
| Subject Keyword | Public Health Nutrition Nutrition and Dietetics Micronutrient Deficiency |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Public Health, Environmental and Occupational Health |
