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A dosimetric comparison of craniospinal irradiation using TomoDirect radiotherapy, TomoHelical radiotherapy and 3D conventional radiotherapy
| Content Provider | Scilit |
|---|---|
| Author | Tsang, Shirley W. S. Collins, Mark Wong, Jacky T. L. Chiu, George |
| Copyright Year | 2017 |
| Description | Aim: The purpose of this study was to dosimetrically compare TomoDirect, TomoHelical and linear accelerator-based 3D-conformal radiotherapy (Linac-3DCRT) for craniospinal irradiation (CSI) in the treatment of medulloblastoma.Methods: Five CSI patients were replanned with Linac-3DCRT, TomoHelical, TomoDirect-3DCRT and TomoDirect-intensity-modulated radiotherapy (IMRT). Dose of 36 Gy in 20 fractions was prescribed to the planning target volume (PTV). Homogeneity index (HI), non-target integral dose (NTID), dose–volume histograms, organs-at-risk $(OARs)D_{max},D_{mean}$and treatment times were compared.Results: TomoHelical achieved the best PTV homogeneity compared with Linac-3DCRT, TomoDirect-3DCRT and TomoDirect-IMRT (HI of 3·6 versus 20·9, 8·7 and 9·4%, respectively). TomoDirect-IMRT achieved the lowest NTID compared with TomoDirect-3DCRT, TomoHelical and Linac-3DCRT (141 J versus 151 J, 181 J and 250 J), indicating least biological damage to normal tissues. TomoHelical plans achieved the $lowestD_{max}$in all organs except the breasts, and $lowestD_{mean}$for most OARs, except in laterally situated OARs, where TomoDirect triumphed. Beam-on time was longest for TomoHelical, followed by TomoDirect and Linac-3DCRT.Findings: TomoDirect has the potential to lower NTID and shorten treatment times compared with TomoHelical. It reduces PTV inhomogeneity and better spares OARs compared with Linac-3DCRT. Therefore, TomoDirect may be a CSI treatment alternative to TomoHelical and in place of Linac-3DCRT. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2523AFE12FA9C5DED00D38698A45EEB6/S1460396917000309a.pdf/div-class-title-a-dosimetric-comparison-of-craniospinal-irradiation-using-tomodirect-radiotherapy-tomohelical-radiotherapy-and-3d-conventional-radiotherapy-div.pdf |
| Ending Page | 402 |
| Page Count | 12 |
| Starting Page | 391 |
| ISSN | 14603969 |
| e-ISSN | 14671131 |
| DOI | 10.1017/s1460396917000309 |
| Journal | Journal of Radiotherapy in Practice |
| Issue Number | 4 |
| Volume Number | 16 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2017-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal of Radiotherapy in Practice Radiology, Nuclear Medicine and Imaging Craniospinal Irradiation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Oncology |
