NDLI: Trans-10,cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway

Please wait, while we are loading the content...

Trans-10,cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway

Content Provider	Scilit
Author	Kim, Dong-In Kim, Keun-Hwa Kang, Ji-Houn Jung, Eui-Man Kim, Sung-Soo Jeung, Eui-Bae Yang, Mhan-Pyo
Copyright Year	2010
Description	The activation of PPARγ by ligands, including conjugated linoleic acid (CLA) isomers, plays an important role in the immune response. Among CLA isomers,trans-10,cis-12 (t10c12)-CLA is known to participate in the modulation of pro-inflammatory cytokine secretion. The aim of the present study was to assess the effect oft10c12-CLA on PPARγ activation, NF-κB activation and TNF-α expression in lipopolysaccharide (LPS)-naive and LPS-stimulated porcine peripheral blood mononuclear cells (PBMC). In addition, the effect of PPARγ inhibition on NF-κB activation and TNF-α expression in porcine PBMC was examined.t10c12-CLA was found to increase TNF-α expression and NF-κB activity in LPS-naive porcine PBMC. In contrast,t10c12-CLA decreased TNF-α expression and NF-κB activity in LPS-stimulated porcine PBMC.t10c12-CLA up-regulated PPARγ activity and mRNA expression in both LPS-naive and LPS-stimulated porcine PBMC. GW9662, a PPARγ antagonist, completely negated the modulating effects oft10c12-CLA on TNF-α expression and NF-κB activity in both LPS-naive and LPS-stimulated porcine PBMC. These results suggest thatt10c12-CLA can modulate TNF-α production and NF-κB activation by a PPARγ-dependent pathway in porcine PBMC.
Related Links	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/F9C905A67503833B23334836093BFA5E/S000711451000499Xa.pdf/div-class-title-span-class-italic-trans-span-10-span-class-italic-cis-span-12-conjugated-linoleic-acid-modulates-nf-b-activation-and-tnf-production-in-porcine-peripheral-blood-mononuclear-cells-via-a-ppar-dependent-pathway-div.pdf
Ending Page	1336
Page Count	8
Starting Page	1329
ISSN	00071145
e-ISSN	14752662
DOI	10.1017/s000711451000499x
Journal	British Journal Of Nutrition
Issue Number	9
Volume Number	105
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2010-12-23
Access Restriction	Open
Subject Keyword	British Journal Of Nutrition conjugated Linoleic Acid Lipopolysaccharide
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in