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A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk
| Content Provider | Scilit |
|---|---|
| Author | Deschasaux, Mélanie Souberbielle, Jean-Claude Latino-Martel, Paule Sutton, Angela Charnaux, Nathalie Druesne-Pecollo, Nathalie Galan, Pilar Hercberg, Serge Clerc, Sigrid Le Kesse-Guyot, Emmanuelle Ezzedine, Khaled Touvier, Mathilde |
| Copyright Year | 2015 |
| Description | Mechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case–control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer $(OR_{Q4 v. Q1}$ 0·30; 95 % CI 0·12, 0·77; $P_{trend}$=0·007). PTH concentration was not associated with prostate cancer risk $(P_{trend}$=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5555C209138B673F2ED80CEDC31F2B73/S0007114515004353a.pdf/div-class-title-a-prospective-study-of-plasma-25-hydroxyvitamin-d-concentration-and-prostate-cancer-risk-div.pdf |
| Ending Page | 314 |
| Page Count | 10 |
| Starting Page | 305 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114515004353 |
| Journal | British Journal Of Nutrition |
| Issue Number | 2 |
| Volume Number | 115 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2015-11-16 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics hydroxyvitamin D Parathyroid Hormone Prostate Cancer Risk Nested Case–control Studies dihydroxyvitamin D sensing Receptor hydroxylase specific Component Minor Allele Frequency Retinoid X Receptor Supplémentation En Vitamines Et Minéraux Antioxydants Vitamin D Receptor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
