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Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
| Content Provider | Scilit |
|---|---|
| Author | Park, Eunyoung Edirisinghe, Indika Choy, Ying Yng Waterhouse, Andrew Burton-Freeman, Britt |
| Copyright Year | 2015 |
| Description | The aim of the present study was to test grape seed extract (GSE) as a functional ingredient to lower blood pressure (BP) in individuals with pre-hypertension. A single-centre, randomised, two-arm, double-blinded, placebo-controlled, 12-week, parallel study was conducted in middle-aged adults with pre-hypertension. A total of thirty-six subjects were randomised (1:1) to Placebo (n18) or GSE (n18) groups; twenty-nine of them completed all the protocol-specified procedures (Placebo,n17; GSE,n12). Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks preceded by a 2-week Placebo run-in and followed by 4-week no-beverage follow-up. Compliance was monitored. BP was measured at screening, 0, 6 and 10 weeks of intervention and blood samples were collected at 0, 3, 6 and 10 weeks of intervention. GSE significantly reduced systolic BP (SBP) by 5·6 % (P=0·012) and diastolic BP (DBP) by 4·7 % (P=0·049) after 6 weeks of intervention period, which was significantly different (SBP;P=0·03) or tended to be different (DBP;P=0·08) from Placebo. BP returned to baseline after the 4-week discontinuation period of GSE beverage. Subjects with higher initial BP experienced greater BP reduction; nearly double the effect size. Fasting insulin and insulin sensitivity tended to improve after 6 weeks of GSE beverage supplementation (P=0·09 and 0·07, respectively); no significant changes were observed with fasting plasma lipids, glucose, oxidised LDL, flow-mediated dilation or vascular adhesion molecules. Total plasma phenolic acid concentrations were 1·6 times higher after 6 weeks of GSEv. Placebo. GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5F6691274A6C0D4D15E934F2403296E9/S0007114515004328a.pdf/div-class-title-effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial-div.pdf http://journals.cambridge.org/article_S0007114515004328 |
| Ending Page | 238 |
| Page Count | 13 |
| Starting Page | 226 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114515004328 |
| Journal | British Journal of Nutrition |
| Issue Number | 2 |
| Volume Number | 115 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2015-11-16 |
| Access Restriction | Open |
| Subject Keyword | British Journal of Nutrition Nutrition and Dietetics Grape Seed Extract Endothelial Function Insulin Sensitivity Bp Blood Pressure mediated Dilation Gse Grape Seed Extract ir Homoeostasis Model Assessment for Insulin Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
