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Cholecystokinin-like immunoreactive amacrine cells in the rat retina
| Content Provider | Scilit |
|---|---|
| Author | Firth, Sally I. Varela, Carolina Villa, Pedro D. E. L. A. Marshak, David W. |
| Copyright Year | 2002 |
| Description | High levels of endogenous cholecystokinin (CCK) are present in the rat retina (Eskay & Beinfeld, 1982), but the cellular localization and physiological actions of CCK in the rat retina are uncertain. The goals of this study were to characterize the cells containing CCK, identify cell types that interact with CCK cells, and investigate the effects of CCK on rod bipolar cells. Rat retinas were labeled with antibody to gastrin-CCK (gCCK) using standard immunofluorescence techniques. Patch-clamp methods were used to record from dissociated rod bipolar cells from rats and mice. Gastrin-CCK immunoreactive (-IR) axons were evenly distributed throughout the retina in stratum 5 of the inner plexiform layer of the rat retina. However, the gCCK-IR somata were only detected in the ganglion cell layer in the peripheral retina. The gCCK-IR cells contained glutamate decarboxylase, and some of them also contained immunoreactive substance P. Labeled axons contacted PKC-IR rod bipolar cells, and recoverin-IR ON-cone bipolar cells. CCK-octapeptide inhibits $GABA_{C}$ but not $GABA_{A}$ mediated currents in dissociated rod bipolar cells. |
| Related Links | http://europepmc.org/articles/pmc3342674?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342674/pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/909369085930FD06D1F2D6B8E092974B/S0952523802194156a.pdf/div-class-title-cholecystokinin-like-immunoreactive-amacrine-cells-in-the-rat-retina-div.pdf |
| Ending Page | 540 |
| Page Count | 10 |
| Starting Page | 531 |
| ISSN | 09525238 |
| e-ISSN | 14698714 |
| DOI | 10.1017/s0952523802194156 |
| Journal | Visual neuroscience |
| Issue Number | 4 |
| Volume Number | 19 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2002-07-01 |
| Access Restriction | Open |
| Subject Keyword | Visual neuroscience Developmental Biology Displaced Amacrine Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Sensory Systems |
