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May the Mediterranean diet attenuate the risk of type 2 diabetes associated with obesity: the Seguimiento Universidad de Navarra (SUN) cohort
| Content Provider | Scilit |
|---|---|
| Author | Eguaras, Sonia Bes-Rastrollo, Maira Ruiz-Canela, Miguel Carlos, Silvia de la Rosa, Pedro Martínez-González, Miguel A. |
| Copyright Year | 2017 |
| Description | It is likely that the Mediterranean diet (MedDiet) may mitigate the adverse effects of obesity on the incidence of type 2 diabetes mellitus (T2DM). We assessed this hypothesis in a cohort of 18 225 participants initially free of diabetes (mean age: 38 years, 61 % women). A validated semi-quantitative 136-item FFQ was used to assess dietary intake and to build a 0–9 score of adherence to MedDiet. After a median of 9·5-year follow-up, 136 incident cases of T2DM were confirmed during 173 591 person-years follow-up. When MedDiet adherence was low (≤4 points), the multivariable-adjusted hazard ratios (HR) were 4·07 (95 % CI 1·58, 10·50) for participants with BMI 25–29·99 $kg/m^{2}$ and 17·70 (95 % CI 6·29, 49·78) $kg/m^{2}$ for participants with BMI≥30 $kg/m^{2}$, (v.4 points), these multivariable-adjusted HR were 3·13 (95 % CI 1·63, 6·01) and 10·70 (95 % CI 4·98, 22·99) for BMI 25–30 and ≥30 $kg/m^{2}$, respectively. The P value for the interaction was statistically significant (P=0·002). When we assessed both variables (BMI and MedDiet) as continuous, the P value for their interaction product-term was marginally significant (P=0·051) in fully adjusted models. This effect modification was not explained by weight changes during follow-up. Our results suggest that the MedDiet may attenuate the adverse effects of obesity on the risk of T2DM. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B59E10E3FE7D659AEA72E6455B3F952E/S0007114517001404a.pdf/div-class-title-may-the-mediterranean-diet-attenuate-the-risk-of-type-2-diabetes-associated-with-obesity-the-seguimiento-universidad-de-navarra-sun-cohort-div.pdf |
| Ending Page | 1485 |
| Page Count | 8 |
| Starting Page | 1478 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114517001404 |
| Journal | British Journal Of Nutrition |
| Issue Number | 10 |
| Volume Number | 117 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2017-05-28 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics Mediterranean Diet Hazard Ratio Prevención Con Dieta Mediterránea Type 2 Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
