NDLI: Emoglobine fetali abnormi nella popolazione italiana

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Emoglobine fetali abnormi nella popolazione italiana

Content Provider	Scilit
Author	Silvestroni, E. Bianco, I.
Copyright Year	1961
Description	SUMMARY: The authors explain 9 cases of Bart's Hb. and one case of Hb. Alexandra, identified on 3.556 blood samples from the umbilical-cord in human newborn in time. Electrophorectical and spectrophotometrical examinations showed that Bart's Hb. is identical to Hb. $H_{2}$ (the least fast of the two Hb. fractions present into the bearers of Hb. H). In 7 newborn infants, it has been possible with Bart's Hb. to reexamine them, some months after they were born; it was observed that the said haemoglobins had disappeared; at the same time, in 4 of those subjects, a clear microcytemic picture was noted while in 3 others, still very small, the microcytemic picture appeared still uncertain. In 8 families with newborn babies with Bart's Hb., the two parents were also examined, and in 7 of these families one of the two parents presented a microcytemic picture; in one of them the hematologic traits were normal in both parents, except a very hight alteration of the eritrocyte morphology in the mother. None of the examined parents presented any abnormal haemoglobin; furthermore, all microcytemic parents (except one) and all children with Bart's Hb. presented a normal rate of Hb. $A_{2}$. This fact, absolutely similar to that observed in the bearers of Hb. H and in their microcytemic relatives, allow to put forward the hypothesis that Bart's Hb. and Hb. H appear in the same families in which we find that special type of microcytemia without any increase of Hb. $A_{2}$, which would correspond to the microcytemia of the α chain.
Related Links	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/17CB0657376BE18FAFA781D292CF31EB/S1120962300016796a.pdf/div-class-title-emoglobine-fetali-abnormi-nella-popolazione-italiana-a-href-fn01-ref-type-fn-span-class-sup-1-span-a-div.pdf
Ending Page	484
Page Count	15
Starting Page	470
ISSN	11209623
e-ISSN	20596316
DOI	10.1017/s1120962300016796
Journal	Acta geneticae medicae et gemellologiae
Issue Number	04
Volume Number	10
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	1961-01-01
Access Restriction	Open
Subject Keyword	Acta geneticae medicae et gemellologiae Medical Laboratory Technology Microcytemic Picture
Content Type	Text
Resource Type	Article

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