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Early programming of adult blood pressure in the low birth weight Yucatan miniature pig is exacerbated by a post-weaning high-salt-fat-sugar diet
| Content Provider | Scilit |
|---|---|
| Author | Myrie, Semone B. Kay, Dylan S. Mac Vliet, Bruce N. Van Bertolo, Robert F. |
| Copyright Year | 2011 |
| Description | We previously demonstrated that intra-uterine growth-restricted (IUGR) Yucatan miniature pigs develop modestly elevated blood pressure (BP) as young adults. The present study evaluated the effects of a post-weaning Western-style, high-salt-fat-sugar (HSFS) diet on early programming of BP. IUGR piglets (3 d old, 0·77 (sem0·04) kg,n6) were paired with normal weight (NW) same-sex littermates (1·14 (sem0·03) kg,n6) and fed milk replacer for 4 weeks. A third littermate was left with the sow (SF; 1·01 (sem0·05) kg,n6). When 4 weeks old, all pigs were placed on a HSFS dietad libitumfor 5 h/d. When 11 months old, telemeters were implanted to measure BP in pigs before (4·5 % NaCl) and after (0·5 % NaCl) a 7 d reduced salt challenge. At necropsy, nephron numbers were determined. Before sexual maturity, IUGR pigs had greater relative feed intake (P < 0·05), and experienced catch-up growth with greater adiposity, with correlations between adiposity and BP (P < 0·05). Adult IUGR pigs had 26–34 % fewer nephrons and higher diastolic BP (107·7 (sem4·9) mmHg,P = 0·044) than NW (97·2 (sem1·8) mmHg) and SF (98·9 (sem5·3) mmHg) pigs. Systolic BP was similar among the three groups, but was significantly elevated compared with levels previously reported for a control diet. Salt restriction reduced BP in all groups (P < 0·05), but with no differences (P>0·05) in the degree of salt sensitivity among groups. In conclusion, a post-weaning Western-style diet exacerbates early programming of diastolic BP in Yucatan miniature swine, whereas systolic BP is more sensitive to postnatal diet. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/57A4947ACA09C7F861AC8C38B8BF340C/S0007114511006696a.pdf/div-class-title-early-programming-of-adult-blood-pressure-in-the-low-birth-weight-yucatan-miniature-pig-is-exacerbated-by-a-post-weaning-high-salt-fat-sugar-diet-div.pdf |
| Ending Page | 1225 |
| Page Count | 8 |
| Starting Page | 1218 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114511006696 |
| Journal | British Journal Of Nutrition |
| Issue Number | 7 |
| Volume Number | 108 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2011-12-16 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics uterine Growth Restriction style Diet |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
