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Supplementation with a low–moderate dose ofn-3 long-chain PUFA has no short-term effect on bone resorption in human adults
| Content Provider | Scilit |
|---|---|
| Author | Appleton, K. M. Fraser, W. D. Rogers, P. J. Ness, A. R. Tobias, J. H. |
| Copyright Year | 2010 |
| Description | Previous research suggests thatn-3 PUFA may play a role in bone health. The present analysis aimed to investigate the impact ofn-3 PUFA supplementation on bone resorption in adult men and women. Serum samples from 113 mild–moderately depressed individuals (twenty-six males and eighty-seven females, aged 18–67 years) randomised to receive 1·48 g EPA+DHA/d (n53) or placebo (n60) for 12 weeks as part of a large recent randomised controlled trial were assayed forn-3 PUFA status and a bone resorption marker, C-terminal cross-linking telopeptide of type 1 collagen (β-CTX). Regression analyses revealed thatn-3 PUFA status following supplementation was associated with randomisation (placebo/n-3 PUFA) (B = 3·25, 95 % CI 2·60, 3·91,P < 0·01). However, β-CTX status following supplementation was not associated with randomisation (B = − 0·01, 95 % CI − 0·03, 0·04). Change in β-CTX status was also not associated with change inn-3 PUFA status (B = − 0·002, 95 % CI − 0·01, 0·01). These findings provide no evidence for an association betweenn-3 PUFA supplementation (1·48 g EPA+DHA/d) for 12 weeks and bone resorption in humans assessed by β-CTX, and suggest thatn-3 PUFA supplementation may be unlikely to be of benefit in preventing bone loss. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C709B3ACB013EA8608CB2A2AE12A8717/S0007114510004861a.pdf/div-class-title-supplementation-with-a-low-moderate-dose-of-span-class-italic-n-span-3-long-chain-pufa-has-no-short-term-effect-on-bone-resorption-in-human-adults-div.pdf |
| Ending Page | 1149 |
| Page Count | 5 |
| Starting Page | 1145 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114510004861 |
| Journal | British Journal Of Nutrition |
| Issue Number | 8 |
| Volume Number | 105 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2010-12-06 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics 3 Pufa Bone Resorption Telopeptide of Type 1 Collagen Randomised Controlled Trials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
