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Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease
| Content Provider | Scilit |
|---|---|
| Author | Flynn, Ryan Allen, Jessica L. Luznik, Leo Macdonald, Kelli P. Paz, Katelyn Alexander, Kylie A. Vulic, Ante Du, Jing Panoskaltsis-Mortari, Angela Taylor, Patricia A. Poe, Jonathan C. Serody, Jonathan S. Murphy, William J. Hill, Geoffrey R. Maillard, Ivan Koreth, John Cutler, Corey S. Soiffer, Robert J. Antin, Joseph H. Ritz, Jerome Chao, Nelson J. Clynes, Raphael A. Sarantopoulos, Stefanie Blazar, Bruce R. |
| Copyright Year | 2015 |
| Description | Key Points Syk is required for increased B-cell activation and cGVHD generation and maintenance. The Syk inhibitor fostamatinib can treat murine cGVHD and increase human cGVHD B-cell death. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/125/26/4085.full.pdf |
| Ending Page | 4094 |
| Page Count | 10 |
| Starting Page | 4085 |
| DOI | 10.1182/blood-2014-08-595470 |
| Journal | Blood |
| Issue Number | 26 |
| Volume Number | 125 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2015-06-25 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Syk Bronchiolitis Mice Dendritic Cells Apoptosis Bone Marrow Human Cgvhd Small Molecule Inhibitor Journal: Blood (Vol- 2018, Issue- 26) |
| Content Type | Text |
| Resource Type | Article |