NDLI: Leukocyte Transfusions: Function of Transfused Granulocytes from Donors with Chronic Myelocytic Leukemia

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Leukocyte Transfusions: Function of Transfused Granulocytes from Donors with Chronic Myelocytic Leukemia

Content Provider	Scilit
Author	Eyre, M. D. Harmon J. Goldstein, M. D. Ira M. Perry, M. D. Seymour Graw, Jr. Robert G.
Copyright Year	1970
Description	The in vivo function of chronic myelocytic leukemia (CML) leukocytes transfused into infected patients with severe neutropenia was evaluated and the results in four representative patients are reported. The intravascular survival, extravascular migration, and phagocytic capacity of these cells appeared normal in two patients without preformed leukoagglutinins. In two other patients who had only small transient increments in circulating granulocytes and severe transfusion reactions, preformed leukoagglutinins were found. The poor granulocyte recoveries in these patients with antibody could probably be explained by splenic sequestration of the transfused cells. These studies provide evidence supporting the use of CML leukocyte transfusions in patients without preformed leukocyte antibodies.
Related Links	https://ashpublications.org/blood/article-pdf/36/4/432/575625/432.pdf
Ending Page	442
Page Count	11
Starting Page	432
DOI	10.1182/blood.v36.4.432.432
Journal	Blood
Issue Number	4
Volume Number	36
Language	English
Publisher	American Society of Hematology
Publisher Date	1970-10-01
Access Restriction	Open
Subject Keyword	Hematology Antibody Survival Function Leukocyte Leukemia Granulocytes Cml Myelocytic Transfused Leukoagglutinins Journal: Blood (Vol- 74, Issue- 4)
Content Type	Text
Resource Type	Article

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