NDLI: Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study

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Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study

Content Provider	Scilit
Author	O'leary, M. Kersey, Jh Ramsay, Nk Kim, T. McGlave, P. Krivit, W. Levitt, S. Filipovich, A. Woods, W. Coccia, P. Nesbit, Me
Copyright Year	1982
Description	The objective of the current study, initiated in 1976, was to improve upon the high relapse rate and subsequent mortality in children and young adults with acute nonlymphocytic leukemia (ANLL). Seventeen patients, ages 6--28, with ANLL in first bone marrow remission, received cyclophosphamide and total body irradiation using a radiation scheme of 750 rad (7.5 Gy) total dose, delivered at a dose rate of 26 rad (26 cGy) per minute. Allogeneic marrow from HLA-matched sibling donors was followed by prophylactic therapy or graft-versus-host disease (GVHD). Median follow-up of the entire group is 20+ mo; survivors have been followed for a minimum of 14+ mo. Interstitial pneumonitis was observed in 6% of patients, and GVHD was observed in 29%. Seventy percent of patients are alive and in complete continuous remission. Two patients have relapsed (at 7 and 24 mo). Actuarial relapse-free survival is 76% at 1 yr and 64% at 5 yr. Quality of life in this disease-free survivors is excellent; all patients are free of active GVHD, receive no maintenance chemotherapy, and have high Karnofsky performances scores. High dose rate total body irradiation plus cyclophosphamide followed by allogeneic BMT may provide an opportunity for long-term complication-free survival in a substantial proportion of children and young adults with ANLL.
Related Links	https://ashpublications.org/blood/article-pdf/60/2/400/589481/400.pdf
Ending Page	403
Page Count	4
Starting Page	400
DOI	10.1182/blood.v60.2.400.400
Journal	Blood
Issue Number	2
Volume Number	60
Language	English
Publisher	American Society of Hematology
Publisher Date	1982-08-01
Access Restriction	Open
Subject Keyword	Hematology Children Survival Bone Marrow Quality of Life Adults Leukemia Cyclophosphamide Rad Nonlymphocytic Journal: Blood (Vol- 50, Issue- 2)
Content Type	Text
Resource Type	Article

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