Striking inverse correlation between IgG anti-F(ab')2 and autoantibody production in patients with cold agglutination

Content Provider	Scilit
Author	Terness, P. Kirschfink, M. Navolan, D. Dufter, C. Kohl, I. Opelz, G. Roelcke, D.
Copyright Year	1995
Description	Previous experiments showed that the physiologic IgG anti-F(ab')2 antibody suppresses the response of human autoreactive B cells. In the present study, we analyzed the IgG anti-F(ab')2 antibody in 293 patients with cold agglutination (CA). Their average IgG anti-F(ab')2 titer was not much different (211 +/- 8.3) from that of 279 healthy persons (195 +/- 6.7). However, CA patients with high anti-F(ab')2 titers had low CA autoantibody titers and vice versa (P = .0028; rho = - 0.175). The stratification of patients according to the auto-antibody's specificity (anti-I, anti-i, anti-Pr) showed an inverse correlation between anti-F(ab')2 and CA in the anti-I group (P = .0057; rho = - 0.180). Interestingly, the association was present only in patients whose disease was caused by noninfectious agents (P < .0001; rho = - 0.423). The inverse correlation argues for an important role of the IgG anti-F(ab')2 in the regulation of autoantibody production in CA patients.
Related Links	https://ashpublications.org/blood/article-pdf/85/2/548/618819/548.pdf
Ending Page	551
Page Count	4
Starting Page	548
DOI	10.1182/blood.v85.2.548.548
Journal	Blood
Issue Number	2
Volume Number	85
Language	English
Publisher	American Society of Hematology
Publisher Date	1995-01-15
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Autoantibody Rho Igg Anti Titers Inverse Correlation Journal: Blood (Vol- 57, Issue- 2)
Content Type	Text
Resource Type	Article