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Fragment D-dimer levels: an objective marker of vaso-occlusive crisis and other complications of sickle cell disease
| Content Provider | Scilit |
|---|---|
| Author | Devine, Dv Kinney, Tr Thomas, Pf Rosse, Wf Greenberg, Cs |
| Copyright Year | 1986 |
| Description | Although abnormalities in coagulation tests have been reported during vaso-occlusive crises in patients with sickle cell disease, objective, readily performed laboratory tests that document the occurrence of this complication have not been available. We examined the relationship between fibrin D-dimer levels and the occurrence of complications in patients with sickle cell disease, using a commercially available latex bead agglutination assay. The patients were either asymptomatic, hospitalized for vaso-occlusive crisis, or had other complications of sickle cell disease including leg ulcers, chronic cholecystitis, aseptic necrosis, joint pain and infection. Fifty-seven percent of 187 samples on 96 patients had elevated levels of fibrin D-dimer. Ninety percent of 75 samples from asymptomatic patients were negative for fibrin D-dimer (less than 1 microgram/ml) but 97% of 29 samples from patients with vaso-occlusive crisis and 85% of 83 samples from patients with other complications of sickle cell disease were positive. In serial studies, worsening or amelioration in clinical complications were reflected in increasing or decreasing levels of fibrin D-dimer, respectively. The molecular species of fibrin identified by the latex agglutination test was shown to be fragment D-dimer by successive immunoprecipitation and protein blot analysis. We conclude that the complications of sickle cell disease, including vaso-occlusive crisis, result in the production of fibrin D-dimer, and its detection may be used as a marker for the presence of the complication. |
| Related Links | https://ashpublications.org/blood/article-pdf/68/1/317/214041/317.pdf |
| Ending Page | 319 |
| Page Count | 3 |
| Starting Page | 317 |
| DOI | 10.1182/blood.v68.1.317.bloodjournal681317 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 68 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1986-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Sickle Cell Disease Dimer Vaso Occlusive Occlusive Crisis Journal: Blood (Vol- 4, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
