NDLI: Lymphocyte Lysosomes and Lysosomal Enzymes in Chronic Lymphocytic Leukemia

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Lymphocyte Lysosomes and Lysosomal Enzymes in Chronic Lymphocytic Leukemia

Content Provider	Scilit
Author	Douglas, Steven D. Cohnen, Georg König, Erika Brittinger, Günter
Copyright Year	1973
Description	Electron microscopic cytochemical and biochemical studies of lysosomal markers have been performed in unstimulated normal and chronic lymphotic leukemia (CLL) lymphocytes. Decreased activities of the lysosomal enzymes acid phosphatase and β-glucuronidase but not of the nonlysosomal enzyme malate dehydrogenase were observed in CLL lymphocytes as compared to normal cells. At the electron microscopic level, the number of membrane-bounded acid phosphatase-positive organelles was diminished in CLL cells. (Average 1.07 per cell profile in normal cells and 0.17 in CLL lymphocytes). The findings indicate that the diminution of acid hydrolase activities in CLL lymphocytes is most likely due to a reduced number of lysosomes, rather than to a diminished enzyme content of these organelles.
Related Links	https://ashpublications.org/blood/article-pdf/41/4/511/577344/511.pdf
Ending Page	518
Page Count	8
Starting Page	511
DOI	10.1182/blood.v41.4.511.511
Journal	Blood
Issue Number	4
Volume Number	41
Language	English
Publisher	American Society of Hematology
Publisher Date	1973-04-01
Access Restriction	Open
Subject Keyword	Enzyme Phosphatase Leukemia Organelles Microscopic Lysosomal Cll Lymphocytes Diminished Journal: Blood (Vol- 74, Issue- 4)
Content Type	Text
Resource Type	Article

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