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Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission
| Content Provider | Scilit |
|---|---|
| Author | Amylon Snyder, Ds Chao, Nj Taguchi, J. Long, Gd Negrin, Rs Nademanee, Ap O'donnell, Schmidt, Gm Stein, As |
| Copyright Year | 1993 |
| Description | Ninety-nine consecutive patients with acute leukemia in first complete remission under age 50 (median age 27 years; age range 1 to 47 years) with a histocompatible sibling donor were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation. Sixty-one patients were diagnosed with acute myelogenous leukemia (AML), 34 patients with acute lymphoblastic leukemia (ALL), 3 patients with biphenotypic acute leukemia, and 1 patient with acute undifferentiated leukemia. Thirty of the 34 patients with ALL had at least one of the following high-risk factors: age greater than 30, white blood cell count at presentation > 25,000/microL, extramedullary disease, certain chromosomal translocations, or the need for greater than 4 weeks of induction chemotherapy to achieve first complete remission. Cumulative probabilities of disease-free survival and relapse at 3 years were 61% and 12%, respectively, for the 61 patients with AML and 64% and 12%, respectively, for the 34 patients with ALL. By stepwise Cox regression analysis, significant prognostic variables for patients with acute myelogenous leukemia were the presence of acute graft-versus-host disease and increasing age, whereas for patients with acute lymphoblastic leukemia, significant variables were age and the development of cytomegalovirus-associated interstitial pneumonia. Complications related to graft-versus-host disease and relapse of leukemia were the major causes of death. |
| Related Links | https://ashpublications.org/blood/article-pdf/82/9/2920/229396/2920.pdf |
| Ending Page | 2928 |
| Page Count | 9 |
| Starting Page | 2920 |
| DOI | 10.1182/blood.v82.9.2920.bloodjournal8292920 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 82 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1993-11-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Bone Marrow Age Acute Leukemia Complete Remission Patients with Acute Journal: Blood (Vol- 107, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
