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Expression of shared idiotypes in chronic lymphocytic leukemia and small lymphocytic lymphoma
| Content Provider | Scilit |
|---|---|
| Author | Swisher, Em Shawler, Dl Collins, Ha Bustria, A. Hart, S. Bloomfield, C. Miller, Ra Royston, I. |
| Copyright Year | 1991 |
| Description | The expression of shared idiotypes (Slds) has been studied on malignant CD5+B cells from patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) using a panel of 37 murine monoclonal antibodies previously demonstrated to be reactive with Slds derived from follicular B-cell lymphomas. Thirteen anti-Slds identified tumor cells from 31 of 105 (30%) CLL patients and 4 of 6 SLL patients. In comparison, the same panel of anti-Slds is reactive with 33% of follicular and diffuse B-cell lymphomas. Ten of these anti-Slds reacted with CLL cases at similar frequencies to that of the B-cell lymphomas. Two anti-Slds, which are known to react with autoantibodies, were significantly more prevalent in CLL than in B-cell lymphomas. These data confirm the presence of Slds in CLL and provide further evidence of an association between CLL and autoimmunity. The identification of a panel of antibodies reactive with a significant number of CLL and SLL patients will facilitate the application of anti-idiotype antibody therapy in these diseases. |
| Related Links | https://ashpublications.org/blood/article-pdf/77/9/1977/221891/1977.pdf |
| Ending Page | 1982 |
| Page Count | 6 |
| Starting Page | 1977 |
| DOI | 10.1182/blood.v77.9.1977.bloodjournal7791977 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 77 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1991-05-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Antibodies Leukemia Lymphocytic Cll Follicular Panel Lymphomas Sll React Slds Journal: Blood (Vol- 107, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
