NDLI: Native human blood dendritic cells as potent effectors in antibody-dependent cellular cytotoxicity

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Native human blood dendritic cells as potent effectors in antibody-dependent cellular cytotoxicity

Content Provider	Scilit
Author	Schmitz, Marc Zhao, Senming Schäkel, Knut Bornhäuser, Martin Ockert, Detlef Rieber, Ernst Peter
Copyright Year	2002
Description	Functional studies on native human dendritic cells (DCs) are hampered by technical difficulties in preparing fresh DCs. Recently, with the help of the monoclonal antibody M-DC8, we succeeded in isolating a major subpopulation of human blood DCs by a one-step immunomagnetic separation procedure. These cells strongly express FcγRIII (CD16) and FcγRII (CD32) and are quite efficient in the antigen-specific activation of naive T cells. Because some Fcγ receptor-bearing cell types are known as effector cells in antibody-dependent cellular cytotoxicity (ADCC), we investigated whether M-DC8+ DCs are capable of effectuating ADCC. In this report we show that freshly prepared M-DC8+ DCs efficiently mediate tumor-directed ADCC and that both types of Fcγ receptors as well as tumor necrosis factor α essentially contribute to the cytotoxic activity. The results provide evidence that, in addition to their pivotal role in primary T-cell activation, a subset of blood DCs displays efficient cytotoxicity in ADCC.
Related Links	https://ashpublications.org/blood/article-pdf/100/4/1502/1256208/h81602001502.pdf
Ending Page	1504
Page Count	3
Starting Page	1502
DOI	10.1182/blood.v100.4.1502.h81602001502_1502_1504
Journal	Blood
Issue Number	4
Volume Number	100
Language	English
Publisher	American Society of Hematology
Publisher Date	2002-08-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antibody Cytotoxicity Functional Antigen Native Cellular Adcc Dcs Dendritic Fcγ Journal: Blood (Vol- 78, Issue- 4)
Content Type	Text
Resource Type	Article

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