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Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia
| Content Provider | Scilit |
|---|---|
| Author | Josephson, Cassandra D. Granger, Suzanne Assmann, Susan F. Castillejo, Marta-Inés Strauss, Ronald G. Slichter, Sherrill J. Steiner, Marie E. Journeycake, Janna M. Thornburg, Courtney D. Bussel, James Grabowski, Eric F. Neufeld, Ellis J. Savage, William Sloan, Steven R. |
| Copyright Year | 2012 |
| Description | Age-group analyses were conducted of patients in the prophylactic platelet dose trial (PLADO), which evaluated the relation between platelet dose per transfusion and bleeding. Hospitalized patients with treatment-induced hypoproliferative thrombocytopenia were randomly assigned to 1 of 3 platelet doses: 1.1 × 1011, 2.2 × 1011, or 4.4 × 1011 platelets/m2 per transfusion, given for morning counts of ≤ 10 000 platelets/μL. Daily hemostatic assessments were performed. The primary end point (percentage of patients who developed grade 2 or higher World Health Organization bleeding) was evaluated in 198 children (0-18 years) and 1044 adults. Although platelet dose did not predict bleeding for any age group, children overall had a significantly higher risk of grade 2 or higher bleeding than adults (86%, 88%, 77% vs 67% of patients aged 0-5 years, 6-12 years, 13-18 years, vs adults, respectively) and more days with grade 2 or higher bleeding (median, 3 days in each pediatric group vs 1 day in adults; P < .001). The effect of age on bleeding differed by disease treatment category and was most pronounced among autologous transplant recipients. Pediatric subjects were at higher risk of bleeding over a wide range of platelet counts, indicating that their excess bleeding risk may be because of factors other than platelet counts. This trial was registered at www.clinicaltrials.gov as #NCT00128713. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/120/4/748.full.pdf |
| Ending Page | 760 |
| Page Count | 13 |
| Starting Page | 748 |
| DOI | 10.1182/blood-2011-11-389569 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 120 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2012-07-26 |
| Access Restriction | Open |
| Subject Keyword | Hematology Age Group Pediatric Platelet Counts Platelet Dose Thrombocytopenia Adults Bleeding Risk Higher Bleeding Journal: Blood (Vol- 79, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
