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RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML
| Content Provider | Scilit |
|---|---|
| Author | Cucchi, David Denys, Barbara Kaspers, Gertjan J. L. Janssen, Jeroen J. W. M. Ossenkoppele, Gert J. Haas, Valérie De Zwaan, C. Michel Heuvel-Eibrink, Marry M. Van Den Philippé, Jan Csikós, Tamás Kwidama, Zinia Moerloose, Barbara De Bont, Eveline S. J. M. De Lissenberg-Witte, Birgit I. Zweegman, Sonja Verwer, Femke Vandepoele, Karl Schuurhuis, Gerrit Jan Sonneveld, Edwin Cloos, Jacqueline |
| Copyright Year | 2018 |
| Description | Key Points FLT3-ITD-AR measurement based on RNA, but not DNA, is predictive for survival with a cutoff point of 0.5. FLT3-ITD-AR is associated with an ex vivo response to FLT3 inhibition with gilteritinib. |
| Related Links | https://ashpublications.org/blood/article-pdf/131/22/2485/1468314/blood819508.pdf |
| Ending Page | 2489 |
| Page Count | 5 |
| Starting Page | 2485 |
| DOI | 10.1182/blood-2017-12-819508 |
| Journal | Blood |
| Issue Number | 22 |
| Volume Number | 131 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-05-31 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Survival Flt3 Itd Ex Vivo Response Response To Flt3 Journal: Blood (Vol- 136, Issue- 22) |
| Content Type | Text |
| Resource Type | Article |