NDLI: Posttransplant chimeric antigen receptor therapy

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Posttransplant chimeric antigen receptor therapy

Content Provider	Scilit
Author	Smith, Melody Zakrzewski, Johannes James, Scott Sadelain, Michel
Copyright Year	2018
Description	Therapeutic T-cell engineering is emerging as a powerful approach to treat refractory hematological malignancies. Its most successful embodiment to date is based on the use of second-generation chimeric antigen receptors (CARs) targeting CD19, a cell surface molecule found in most B-cell leukemias and lymphomas. Remarkable complete remissions have been obtained with autologous T cells expressing CD19 CARs in patients with relapsed, chemo-refractory B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma. Allogeneic CAR T cells may also be harnessed to treat relapse after allogeneic hematopoietic stem cell transplantation. However, the use of donor T cells poses unique challenges owing to potential alloreactivity. We review different approaches to mitigate the risk of causing or aggravating graft-versus-host disease (GVHD), including CAR therapies based on donor leukocyte infusion, virus-specific T cells, T-cell receptor–deficient T cells, lymphoid progenitor cells, and regulatory T cells. Advances in CAR design, T-cell selection and gene editing are poised to enable the safe use of allogeneic CAR T cells without incurring GVHD.
Related Links	https://ashpublications.org/blood/article-pdf/131/10/1045/1405453/blood752121.pdf
Ending Page	1052
Page Count	8
Starting Page	1045
DOI	10.1182/blood-2017-08-752121
Journal	Blood
Issue Number	10
Volume Number	131
Language	English
Publisher	American Society of Hematology
Publisher Date	2018-03-08
Access Restriction	Open
Subject Keyword	Hematology Research and Experimental Medicine Hematopoietic Virus Lymphoma Gvhd Leukemia Relapse Antigen Cd19 Chimeric Donor Journal: Blood (Vol- 115, Issue- 10)
Content Type	Text
Resource Type	Article

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