NDLI: Anti-RH immunoglobulin therapy for human immunodeficiency virus-related immune thrombocytopenic purpura

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Anti-RH immunoglobulin therapy for human immunodeficiency virus-related immune thrombocytopenic purpura

Content Provider	Scilit
Author	Oksenhendler, E. Bierling, P. Brossard, Y. Schenmetzler, C. Girard, Pm Seligmann, M. Clauvel, Jp
Copyright Year	1988
Description	The potential hazards of steroids in human immunodeficiency virus (HIV)- infected patients led us to evaluate the effectiveness and safety of anti-D and anti-c Ig in 17 adults with severe HIV-related immune thrombocytopenic purpura (platelet count less than 20 x 10(9)/L). The 14 Rh+ patients received 12 to 25 micrograms/kg of anti-D IgG intravenously on two consecutive days. A significant platelet rise above 50 x 10(9)/L was obtained in nine patients. Repeated boosters were performed in six cases and were effective in all cases. The 3 Rh- patients had a good response after they were given 20 mL x 2 of plasma containing potent anti-c antibodies. Therapy was well tolerated, and only one patient had significant hemolysis. These data suggest that anti-Rh IgG can be effective and safe in HIV-related thrombocytopenic purpura and that a specific interaction between the RBC antigens and the anti-Rh antibodies is required.
Related Links	https://ashpublications.org/blood/article-pdf/71/5/1499/598118/1499.pdf
Ending Page	1502
Page Count	4
Starting Page	1499
DOI	10.1182/blood.v71.5.1499.1499
Journal	Blood
Issue Number	5
Volume Number	71
Language	English
Publisher	American Society of Hematology
Publisher Date	1988-05-01
Access Restriction	Open
Subject Keyword	Hematology Antibodies Virus Hiv Antigens Adults Platelet Thrombocytopenic Purpura Anti Rh Journal: Blood (Vol- 82, Issue- 5)
Content Type	Text
Resource Type	Article

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