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The relationship between anemia, fecal stercobilinogen, erythrocyte survival, and globin synthesis in heterozygotes for beta-thalassemia
| Content Provider | Scilit |
|---|---|
| Author | Gallo, E. Pich, P. Ricco, G. Saglio, G. Camaschella, C. Mazza, U. |
| Copyright Year | 1975 |
| Description | Erythrocyte survival, fecal stercobilinogen, and the alpha/beta-chain synthesis ratio in recticulocytes and bone marrow (six cases only) were determined and related to the hemoglobin levels in ten heterozygous carriers of beta-thalassemia with different degrees of anemia. Erythrocyte survival values were low, though not related to the degree of anemia, whereas stercobilinogen values and changes in the peripheral blood alpha/beta-chain ratios were so correlated. In the case of bone marrow, on the other hand, the ratio between alpha-chain and beta-chain synthesis was virtually 1, irrespective of the degree of anemia. It is suggested that the severity of anemia in heterozygous carriers is independent of peripheral hemolysis and entirely attributable to destruction of erythroblasts within the marrow. |
| Related Links | https://ashpublications.org/blood/article-pdf/46/5/693/203629/693.pdf |
| Ending Page | 698 |
| Page Count | 6 |
| Starting Page | 693 |
| DOI | 10.1182/blood.v46.5.693.bloodjournal465693 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 46 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1975-11-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Medical Laboratory Technology Bone Marrow Anemia Thalassemia Fecal Alpha/beta Erythrocyte Survival Stercobilinogen Journal: Blood (Vol- 80, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
