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Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa
| Content Provider | Scilit |
|---|---|
| Author | Chunda-Liyoka, C. Kumar, A. A. Sambo, P. Lubinda, F. Nchimba, L. Humpton, T. Okuku, P. Miyanda, C. Im, J. Maguire, K. Whitesides, G. M. Stossel, T. P. |
| Copyright Year | 2018 |
| Description | We have developed a simple, low-cost and innovative test to screen for SCD using aqueous multiphase systems (AMPSs) that form immiscible self-assembling step-gradients. An AMPS designed to target the density signature of sickle cell anemia forms the basis of this novel multi-phase analyzer (named MPANA) diagnostic technique. MPANA consists of an AMPS-filled capillary tube. A drop of blood obtained from an individual by finger prick and introduced into the tube is subjected to centrifugation for 15 minutes in a small rotor powered by an automobile battery. The centrifugal force causes blood cells to separate according to their density. Because deformed SCD red blood cells are very dense, after centrifugation they form a red button visible to the naked eye at the bottom of the tube. The estimated cost per test is 50 $cents.^{1}$ |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438268/pdf |
| Ending Page | 3 |
| Page Count | 3 |
| Starting Page | 1 |
| DOI | 10.1182/bloodadvances.2018gs112321 |
| Journal | Blood advances |
| Issue Number | Supplement |
| Volume Number | 2 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-11-30 |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology Africa Form Tube Blood Cells Scd Sickle Cell Centrifugation Amps Mpana Journal: Blood advances (Vol- 2021, Supplement) |
| Content Type | Text |
| Resource Type | Article |
