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HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway
| Content Provider | Scilit |
|---|---|
| Author | Jiang, Xiaoyu Lu, Xiaoqing McNamara, George Liu, Xiaofei Cubedo, Elena Sarosiek, Kristopher Sanchez-Garcia, Isidro Helfman, David M. Lossos, Izidore S. |
| Copyright Year | 2010 |
| Description | HGAL is a germinal center (GC)–specific gene that negatively regulates lymphocyte motility and whose expression predicts improved survival of patients with diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). We demonstrate that HGAL serves as a regulator of the RhoA signaling pathway. HGAL enhances activation of RhoA and its down-stream effectors by a novel mechanism – direct binding to the catalytic DH-domain of the RhoA-specific guanine nucleotide exchange factors (RhoGEFs) PDZ-RhoGEF and LARG that stimulate the GDP-GTP exchange rate of RhoA. We delineate the structural domain of HGAL that mediates its interaction with the PDZ-RhoGEF protein. These observations reveal a novel molecular mechanism underlying the inhibitory effects of GC-specific HGAL protein on the motility of GC-derived lymphoma cells. This mechanism may underlie the limited dissemination and better outcome of patients with HGAL-expressing DLBCL and cHL. |
| Related Links | https://ashpublications.org/blood/article-pdf/116/24/5217/1462229/zh805010005217.pdf |
| Ending Page | 5227 |
| Page Count | 11 |
| Starting Page | 5217 |
| DOI | 10.1182/blood-2010-04-281568 |
| Journal | Blood |
| Issue Number | 24 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2010-12-09 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Protein Survival Pdz Motility Lymphoma Rhoa Rhogef Germinal Hgal Journal: Blood (Vol- 138, Issue- 24) |
| Content Type | Text |
| Resource Type | Article |
