NDLI: Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts

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Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts

Content Provider	Scilit
Author	Blau, Olga Baldus, Claudia Dorothea Hofmann, Wolf-Karsten Thiel, Gundula Nolte, Florian Burmeister, Thomas Türkmen, Seval Benlasfer, Ouidad Schümann, Elke Sindram, Annette Molkentin, Mara Mundlos, Stefan Keilholz, Ulrich Thiel, Eckhard Blau, Igor Wolfgang
Copyright Year	2011
Description	Mesenchymal stromal cells (MSCs) are an essential cell type of the hematopoietic microenvironment. Concerns have been raised about the possibility that MSCs undergo malignant transformation. Several studies, including one from our own group, have shown the presence of cytogenetic abnormalities in MSCs from leukemia patients. The aim of the present study was to compare genetic aberrations in hematopoietic cells (HCs) and MSCs of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) patients. Cytogenetic aberrations were detected in HCs from 25 of 51 AML patients (49%) and 16 of 43 MDS patients (37%). Mutations of the FLT3 and NPM1 genes were detected in leukemic blasts in 12 (23%) and 8 (16%) AML patients, respectively. Chromosomal aberrations in MSCs were detected in 15 of 94 MDS/AML patients (16%). No chromosomal abnormalities were identified in MSCs of 36 healthy subjects. We demonstrate herein that MSCs have distinct genetic abnormalities compared with leukemic blasts. We also analyzed the main characteristics of patients with MSCs carrying chromosomal aberrations. In view of these data, the genetic alterations in MSCs may constitute a particular mechanism of leukemogenesis.
Related Links	https://ashpublications.org/blood/article-pdf/118/20/5583/1345710/zh804611005583.pdf
Ending Page	5592
Page Count	10
Starting Page	5583
DOI	10.1182/blood-2011-03-343467
Journal	Blood
Issue Number	20
Volume Number	118
Language	English
Publisher	American Society of Hematology
Publisher Date	2011-11-17
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Hematopoietic Leukemic Blasts Distinct Mscs Compared with Leukemic Abnormalities Compared Genetic Abnormalities Journal: Blood (Vol- 132, Issue- 20)
Content Type	Text
Resource Type	Article

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