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Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production
| Content Provider | Scilit |
|---|---|
| Author | Dover, Gj Humphries, Rk Moore, Jg Ley, Tj Young, Ns Charache, S. Nienhuis, Aw |
| Copyright Year | 1986 |
| Description | Initial alterations in fetal hemoglobin (HbF) production among eight sickle cell anemia subjects treated with hydroxyurea (Hu) are summarized. Four of these subjects had been previously treated with 5- azacytidine (5-aza). All subjects treated with Hu (50 mg/kg/d for three to five days) had suppression of their total reticulocyte counts by seven days, whereas the four subjects previously treated with 5-aza (2 mg/kg/d for three to five days) had increased reticulocyte counts at day 7. The effect of Hu on increasing the number of HbF-containing reticulocytes (F reticulocytes) is extremely variable, ranging from ten- to less than onefold differences in maximal posttherapy v pretherapy levels. Recovery from marrow suppression did not result in greater than twofold increases in F reticulocyte counts. Mean day 7 F reticulocyte levels in the four subjects treated with both Hu and 5-aza were 4.1 X 10/microL and 15.4 X 10(4)/microL, respectively. Among Hu-treated subjects, increased F reticulocyte production was correlated with low serum creatinine levels and rapid removal of Hu from the plasma. Furthermore, suppression of CFU-E colony formation on day 2 of therapy with Hu was inversely correlated with maximal F reticulocyte response. We conclude that where Hu treatment results in marrow toxicity (decreased reticulocyte counts, decreased CFU-E colony formation) HbF production is less likely to increase. Those sickle cell anemia subjects with minimal renal dysfunction (serum creatinine level, greater than 1.0 mg/dL) exhibit the most cytotoxicity and least F reticulocyte response to Hu. |
| Related Links | https://ashpublications.org/blood/article-pdf/67/3/735/363345/735.pdf |
| Ending Page | 738 |
| Page Count | 4 |
| Starting Page | 735 |
| DOI | 10.1182/blood.v67.3.735.bloodjournal673735 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 67 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1986-03-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Hbf Aza Sickle Cell Extremely Reticulocyte Counts Subjects Treated Journal: Blood (Vol- 66, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
