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Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Hoang, T. Haman, A. Goncalves, O. Wong, Gg Clark, Sc |
| Copyright Year | 1988 |
| Description | The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony- stimulating factor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors. |
| Related Links | https://ashpublications.org/blood/article-pdf/72/2/823/600156/823.pdf |
| Ending Page | 826 |
| Page Count | 4 |
| Starting Page | 823 |
| DOI | 10.1182/blood.v72.2.823.823 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-08-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Bone Marrow Proliferation Leukemia Progenitors Colony Erythroid Stimulating Myeloblastic Synergized Journal: Blood (Vol- 54, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
