Loading...
Please wait, while we are loading the content...
Similar Documents
Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice
| Content Provider | Scilit |
|---|---|
| Author | Tsukiji, Nagaharu Osada, Makoto Sasaki, Tomoyuki Shirai, Toshiaki Satoh, Kaneo Inoue, Osamu Umetani, Norihiko Mochizuki, Chihiro Saito, Tamio Kojima, Soichi Shinmori, Hideyuki Ozaki, Yukio Suzuki-Inoue, Katsue |
| Copyright Year | 2018 |
| Description | Key Points Co-HP binds to CLEC-2 at N120 and K211, novel binding sites for podoplanin, and inhibits their interaction. Co-HP prevents hematogenous tumor metastasis and arterial/venous thrombosis in mice, without a significant increase in bleeding time. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134222/pdf |
| Ending Page | 2225 |
| Page Count | 12 |
| Starting Page | 2214 |
| DOI | 10.1182/bloodadvances.2018016261 |
| Journal | Blood advances |
| Issue Number | 17 |
| Volume Number | 2 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-09-06 |
| Access Restriction | Open |
| Subject Keyword | Hematology Lung Metastasis Receptor Platelet Thrombosis Bleeding Time Co Hp Podoplanin Binding Inhibits Clec Journal: Blood advances (Vol- 127, Issue- 17) |
| Content Type | Text |
| Resource Type | Article |