NDLI: Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Content Provider	Scilit
Author	Dulmovits, Brian M. Appiah-Kubi, Abena O. Papoin, Julien Hale, John He, Mingzhu Al-Abed, Yousef Didier, Sebastien Gould, Michael Husain-Krautter, Sehba Singh, Sharon A. Chan, Kyle W. H. Vlachos, Adrianna Allen, Steven Taylor, Naomi Marambaud, Philippe An, Xiuli Gallagher, Patrick G. Mohandas, Narla Lipton, Jeffrey M. Liu, Johnson M. Blanc, Lionel
Copyright Year	2016
Description	Key Points Pomalidomide selectively targets BCL11A and SOX6 to induce γ-globin synthesis. The mechanism of action of pomalidomide during erythropoiesis is independent of IKZF1 degradation, in contrast to multiple myeloma.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797024/pdf
Ending Page	1492
Page Count	12
Starting Page	1481
DOI	10.1182/blood-2015-09-667923
Journal	Blood
Issue Number	11
Volume Number	127
Language	English
Publisher	American Society of Hematology
Publisher Date	2016-03-17
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Multiple Myeloma Reprogramming Hematopoietic Adult Pomalidomide Progenitors Sox6 Γ Globin Journal: Blood (Vol- 118, Issue- 11)
Content Type	Text
Resource Type	Article

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