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Leukocyte depletion of random single-donor platelet transfusions does not prevent secondary human leukocyte antigen-alloimmunization and refractoriness: a randomized prospective study
| Content Provider | Scilit |
|---|---|
| Author | Sintnicolaas, K. Kooij, M. Van Marwijk Prooijen, Hc Van Dijk, Ba Van Putten, Wl Van Claas, Fh Novotny, Vm Brand, A. |
| Copyright Year | 1995 |
| Description | We studied the value of leukocyte depletion of platelet transfusions for the prevention of secondary human leukocyte antigen (HLA)- alloimmunization in patients with a high-risk of prior immunization induced by pregnancies. Seventy-five female patients with hematologic malignancies (mostly acute leukemia) and a history of pregnancy were randomized to receive either standard random single-donor platelet transfusions (mean leukocytes, 430 x 10(6) per transfusion) or leukocyte-depleted random single-donor platelet transfusions. Leukocyte depletion to less than 5 x 10(6) leukocytes per platelet transfusion (mean leukocytes, 2 x 10(6) per transfusion) was achieved by filtration. Of the 62 evaluable patients, refractoriness to random donor platelets occurred in 41% (14 of 34) of the patients in the standard group and in 29% (8 of 28) of the patients in the filtered group (P = .52); anti-HLA antibodies developed in 43% (9 of 21) of individuals in the standard group and 44% (11 of 25) of cases in the filtered group. The time toward refractoriness and development of anti- HLA antibodies was similar for both groups. We conclude that leukocyte depletion of random single-donor platelet products to less than 5 x 10(6) per transfusion does not reduce the incidence of refractoriness to random donor platelet transfusion because of boostering of anti-HLA antibodies. |
| Related Links | https://ashpublications.org/blood/article-pdf/85/3/824/614995/824.pdf |
| Ending Page | 828 |
| Page Count | 5 |
| Starting Page | 824 |
| DOI | 10.1182/blood.v85.3.824.bloodjournal853824 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 85 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1995-02-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Antibodies Platelet Transfusions Antigen Leukocyte Depletion Donor Platelet Journal: Blood (Vol- 69, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
