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Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation
| Content Provider | Scilit |
|---|---|
| Author | Nemunaitis, J. Singer, Jw Buckner, Cd Durnam, D. Epstein, C. Hill, R. Storb, R. Thomas, Ed Appelbaum, Fr |
| Copyright Year | 1990 |
| Description | The effect of recombinant human granulocyte-macrophage colony- stimulating factor (rhGM-CSF) was evaluated in 37 patients with marrow graft failure after allogeneic (n = 15), autologous (n = 21), or syngeneic (n = 1) bone marrow transplantation. rhGM-CSF was administered by 2-hour infusion at doses between 60 and 1,000 micrograms/m2/d for 14 or 21 days. At doses of less than 500 micrograms/m2, rhGM-CSF was well-tolerated and did not exacerbate graft- versus-host disease in allogeneic transplant recipients. No patient with myelogenous leukemia relapsed while receiving rhGM-CSF. Twenty-one patients reached an absolute neutrophil count (ANC) greater than or equal to 0.5 x 10(9)/L within 2 weeks of starting therapy while 16 did not. None of seven patients who received chemically purged autologous marrow grafts responded to rhGM-CSF. The survival rates of GM-CSF- treated patients were significantly better than those of a historical control group. |
| Related Links | https://ashpublications.org/blood/article-pdf/76/1/245/603765/245.pdf |
| Ending Page | 253 |
| Page Count | 9 |
| Starting Page | 245 |
| DOI | 10.1182/blood.v76.1.245.245 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 76 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1990-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Graft Rhgm Csf Granulocyte Stimulating Macrophage Recombinant Journal: Blood (Vol- 5, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
